Circulating miR-146a -5p in Egyptian patients with Rheumatoid Arthritis

We indented to evaluate of the role miRNA-146a-5p expression level as a possible biomarker associated with incidence rheumatoid arthritis and detection its relevance different disease parameters. The study included 60 clinically diagnosed RA patients fulfilling 2010 American College Rheumatology / European League Against Rheumatism (ACR/EULAR) classification criteria for Rheumatoid Arthritis 45 age sex matched control subjects. Disease activity was assessed by Activity Score 28 (DAS28). levels miR-146a in whole blood measured using reverse transcriptase quantitative real time polymerase chain reaction (RT-PCR). There median significantly higher compared group (P = 0.036). MiR-146a positively correlated individual markers, including erythrocyte sedimentation rate (ESR) 0.04), visual analogue scale (VAS) 0.047) Modified Health Assessment Questionnaire (MHAQ) 0.050). A lower detected on antimalarial drugs whose treatment protocol did not include 0.016). In conclusion, data this suggested association between miRNA 146a-5p Egyptian patients.